- identification of anti-estrogenic activity by inhibition of natural estrus reaction in female rats;
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| Proestrus | Estrus | Metestrus
(resting phase 1) |
Diestrus
(resting phase 2) |
| Identification of estrous cycle stage: cytogram of vaginal smears in rats | |||
- analysis of anti-estrogenic uterotropic activity by reduction of uterine weight of infantile mice and rats;
- analysis of estrogenic activity by appearance of estrus reaction in castrated female mice and rats;
- analysis of estrogenic uterotropic activity by increase in uterine weight in immature mice and rats;
- assessment of androgenic and anti-androgenic activity (Hershberger test);
- assessment of gestagenic activity by influence on differentiation of endometrium in immature female rats and rabbits (Clauberg-McPhail test);
- assessment of gestagenic activity by keeping pregnancy in ovariectomized rats;
- assessment of efficiency of drugs used in treating some forms of infertility: study of follicle stimulating activity in the model of induction of growth and maturation of oocytes;
- assessment of follicle stimulating activity (Steelman-Pohley test);
- study of a spectrum of new hormones action by assessing the levels of sex hormones in blood plasma of experimental animals;
- assessment of glucocorticoid/anti-glucocorticoid activity in thymolytic test;
- study of mineralocorticoids/anti mineralocorticoid activity by changing the level of daily diuresis and urinary sodium excretion in rats;
- assessment of PA activity in the model of experimental osteoporosis in female Wistar rats;
- study of PA activity in the model of experimental hyperthyroidism;
- study of PA activity in the model of experimental hypothyroidism;
- study of the role of sex hormones in pathogenesis of chronic pain syndrome;
- study of the influence of sex hormones on formation of tolerance and sensitization to psychoactive substances;