Study of hormonal pharmaceuticals for systemic use

  • identification of anti-estrogenic activity by inhibition of natural estrus reaction in female rats;
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Proestrus Estrus Metestrus

(resting phase 1)

Diestrus

(resting phase 2)

 Identification of estrous cycle stage: cytogram of vaginal smears in rats
  • analysis of anti-estrogenic uterotropic activity by reduction of uterine weight of infantile mice and rats;
  • analysis of estrogenic activity by appearance of estrus reaction in castrated female mice and rats;
  • analysis of estrogenic uterotropic activity by increase in uterine weight in immature mice and rats;
  • assessment of androgenic and anti-androgenic activity (Hershberger test);
  • assessment of gestagenic activity by influence on differentiation of endometrium in immature female rats and rabbits (Clauberg-McPhail test);
  • assessment of gestagenic activity by keeping pregnancy in ovariectomized rats;
  • assessment of efficiency of drugs used in treating some forms of infertility: study of follicle stimulating activity in the model of induction of growth and maturation of oocytes;
  • assessment of follicle stimulating activity (Steelman-Pohley test);
  • study of a spectrum of new hormones action by assessing the levels of sex hormones in blood plasma of experimental animals;
  • assessment of glucocorticoid/anti-glucocorticoid activity in thymolytic test;
  • study of mineralocorticoids/anti mineralocorticoid activity by changing the level of daily diuresis and urinary sodium excretion in rats;
  • assessment of PA activity in the model of experimental osteoporosis in female Wistar rats;
  • study of PA activity in the model of experimental hyperthyroidism;
  • study of PA activity in the model of experimental hypothyroidism;
  • study of the role of sex hormones in pathogenesis of chronic pain syndrome;
  • study of the influence of sex hormones on formation of tolerance and sensitization to psychoactive substances;