Acute toxicity

  • Acute toxicity is examined according to the Manual for conduting preclinical studies of drugs. Under the editorship of Mironov A.N., Bunatyan N.D. et al., M., publishing house “Grif and K”, 2012;
  • Toxicological study of pharmaceuticals to identify threshold doses (DRF-protocol) FDA Guideline for Industry Toxicokinetics: The Assessment of Systemic Exposure in Toxicity Studies and ICH – M4S;
  • Study of acute toxicity is performed according to OECD protocols on testing of chemicals:
402 Acute dermal toxicity
403 Acute inhalation toxicity
404 Acute dermal irritation|corrosion
405 Acute eye irritation|corrosion
420 Acute oral toxicity – fixed dose procedure
423 Acute oral toxicity – class method
425 Acute oral toxicity, up and down procedure
436 Acute inhalation toxicity, class method
439 In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method