Laboratory animals

No study of the new drug is not without animal research. This allows to determine the pharmacodynamics and pharmacokinetics of the substance, as well as to identify different adverse side effects that are associated with the use of the drug, to avoid the appearance of these effects in patients in the future.

In accordance with the Federal Law of July 13, 2015 N 243-FZ “On Amendments to the Law of the Russian Federation” On veterinary medicine “and Certain Legislative Acts of the Russian Federation”, “NPO” HOUSE OF PHARMACY ” has veterinary certificate:  Veterinary certificate 2017

To ensure the quality of our research, we use the animals or own breeding obtained in the own nursery of laboratory animals or from reliable sources.

On the territory of our organization has:

Laboratory Animal Breeding Facility and Vivarium.

Today we have for research:

Species animal Line Application in non-clinical trials

Mice (Muridae Mus)

outbred

Balb/с

C57BL

CBA

DBA

Toxicology

Pharmacology

A large range of modeling diseases

 

Hamsters (Cricetidae)

outbred

Rats (Muridae Rattus)

outbred

WistarSHR

Guinea pigs (Cavia)

outbred

The specific types of toxicity

Disease models associated with hyperactive immune response

Gerbils, sand rat (Muridae Gerbillinae)

outbred

Pharmacology. Used primarily for the simulation of stroke, diabetes, obesity, gastric ulcer induced by Helicobacter pylori, inflammatory diseases

Degu (Chilean squirrel) (Octodon degus)

outbred

  Pharmacology. Used primarily for modeling Alzheimer’s disease, diabetes and related complications

Rabbits (Leporidae Oryctolagus Cuniculus)

New Zealand

California

Soviet Chinchilla

Toxicology (mainly in the study of finished dosage forms without destroying the integrity of the tablets / capsules)

Pharmacokinetics

Pharmacology (mainly for the simulation of atherosclerosis and other dislipoproteinemia, thrombosis, diseases of the musculoskeletal system, eye diseases, infectious diseases)

For developments antibodies

Mini-pigs (Sus salvanius, Porcula salvania)

outbred

Bishtrasser Knaus

Toxicology. Advantageously, in the study of long-term chronic toxicity to clarify the target organs. The resulting data is used to recalculate the doses Phase I clinical trial to evaluate the maximum safe initial dose at volunteers.

Immunogenicity of biopharmaceuticals

Pharmacokinetics

Pharmacology (mainly for modeling diseases of the cardiovascular system, skin, metabolic disorders (obesity, diabetes, atherosclerosis), for developing new operational approaches (including dental)

Ferrets (Mustelaputorius furo)

outbred

Toxicology. Carcinogenicity.

Pharmacology. Used primarily for modeling of infectious diseases (influenza, measles), cardiovascular diseases, vomiting, cough, diseases of hearing and vision, the study of the effectiveness of chemotherapy.